Coronary Artery Calcium Score and Association with Recurrent Nephrolithiasis: The Multi-Ethnic Study of Atherosclerosis

No AccessJournal of UrologyAdult Urology1 Apr 2016Coronary Artery Calcium Score and Association with Recurrent Nephrolithiasis: The Multi-Ethnic Study of Atherosclerosis Ryan S. Hsi, Andrew J. Spieker, Marshall L. Stoller, David R. Jacobs, Alex P. Reiner, Robyn L. McClelland, Arnold J. Kahn, Thomas Chi, Moyses Szklo, and Mathew D. Sorensen Ryan S. HsiRyan S. Hsi Department of Urology, School of Medicine, University of Washington, Seattle, Washington , Andrew J. SpiekerAndrew J. Spieker Department of Biostatistics, University of Washington, Seattle, Washington , Marshall L. StollerMarshall L. Stoller Department of Urology, University of California-San Francisco, San Francisco , David R. JacobsDavid R. Jacobs Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota , Alex P. ReinerAlex P. Reiner Department of Epidemiology, University of Washington, Seattle, Washington Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington , Robyn L. McClellandRobyn L. McClelland Department of Biostatistics, University of Washington, Seattle, Washington , Arnold J. KahnArnold J. Kahn Buck Institute for Research on Aging, Novato, California , Thomas ChiThomas Chi Department of Urology, University of California-San Francisco, San Francisco , Moyses SzkloMoyses Szklo Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland , and Mathew D. SorensenMathew D. Sorensen Department of Urology, School of Medicine, University of Washington, Seattle, Washington Division of Urology, Department of Veterans Affairs Medical Center, Seattle, Washington Division of Urology, Department of Veterans Affairs Medical Center, Seattle, Washington View All Author Informationhttps://doi.org/10.1016/j.juro.2015.10.001AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Subclinical coronary artery calcification is an established predictor of cardiovascular events. While a history of kidney stones has been linked to subclinical carotid atherosclerosis, to our knowledge no study has examined its relationship with coronary artery calcification. We studied the association between kidney stone history and prevalent coronary artery calcification in MESA (Multi-Ethnic Study of Atherosclerosis). Materials and Methods: MESA is a multisite cohort study of participants 45 to 84 years old without known cardiovascular disease at baseline from 2000 to 2002. Computerized tomography was done in 3,282 participants at followup in 2010 to 2012 to determine coronary artery calcification and kidney stone history was assessed by self-report. Coronary artery calcification scores were categorized as none—0, mild—1 to 99, moderate—100 to 399 or severe—400 or greater. Cross-sectional analysis was performed adjusting for demographic and dietary factors related to kidney stones. Results: The prevalence of kidney stone disease history was approximately 9%, mean ± SD participant age was 69.5 ± 9.3 years, 39% of participants were Caucasian, 47% were men and 69% had detectable coronary artery calcification (score greater than 0). No difference in the score was seen between single stone formers and nonstone formers. Recurrent kidney stone formation was associated with moderate or severe calcification on multivariable logistic regression vs none or mild calcification (OR 1.80, 95% CI 1.22–2.67). When coronary artery calcification scores were separated into none, mild, moderate and severe calcification, recurrent stone formation was associated with a higher score category on multivariable ordinal logistic regression (OR 1.44 per category, 95% CI 1.04–2.01). Conclusions: Recurrent kidney stone formation is associated with subclinical coronary atherosclerosis. This association appeared stronger with coronary artery calcification severity than with coronary artery calcification presence. References 1 : Kidney stones and the risk for chronic kidney disease. Clin J Am Soc Nephrol2009; 4: 804. Google Scholar 2 : Nephrolithiasis and risk of hypertension. Am J Hypertens1998; 11: 46. Google Scholar 3 : Obesity, weight gain, and the risk of kidney stones. JAMA2005; 293: 455. 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Google Scholar © 2016 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byCrivelli J, Maalouf N, Paiste H, Wood K, Hughes A, Oates G and Assimos D (2021) Disparities in Kidney Stone Disease: A Scoping ReviewJournal of Urology, VOL. 206, NO. 3, (517-525), Online publication date: 1-Sep-2021.Assimos D (2019) Re: Urinary Proteomics Reveals Association between Pediatric Nephrolithiasis and Cardiovascular DiseaseJournal of Urology, VOL. 201, NO. 2, (224-224), Online publication date: 1-Feb-2019.Assimos D (2019) Re: Systemic Succinate Homeostasis and Local Succinate Signaling Affect Blood Pressure and Modify Risks for Calcium Oxalate LithogenesisJournal of Urology, VOL. 202, NO. 2, (203-204), Online publication date: 1-Aug-2019.Assimos D (2019) Re: Evaluation of Inactive Matrix-Gla-Protein (MGP) as a Biomarker for Incident and Recurrent Kidney StonesJournal of Urology, VOL. 202, NO. 6, (1092-1092), Online publication date: 1-Dec-2019.Assimos D (2017) Re: Vascular Disease and Kidney Stones: Abdominal Aortic Calcifications are Associated with Low Urine pH and HypocitraturiaJournal of Urology, VOL. 198, NO. 6, (1203-1204), Online publication date: 1-Dec-2017. Volume 195Issue 4 Part 1April 2016Page: 971-976 Advertisement Copyright & Permissions© 2016 by American Urological Association Education and Research, Inc.Keywordsarteriosclerosiskidneycoronary artery diseaserecurrenceurolithiasisAcknowledgmentsA full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org.MetricsAuthor Information Ryan S. Hsi Department of Urology, School of Medicine, University of Washington, Seattle, Washington More articles by this author Andrew J. Spieker Department of Biostatistics, University of Washington, Seattle, Washington More articles by this author Marshall L. Stoller Department of Urology, University of California-San Francisco, San Francisco More articles by this author David R. Jacobs Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota More articles by this author Alex P. Reiner Department of Epidemiology, University of Washington, Seattle, Washington Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington More articles by this author Robyn L. McClelland Department of Biostatistics, University of Washington, Seattle, Washington More articles by this author Arnold J. Kahn Buck Institute for Research on Aging, Novato, California More articles by this author Thomas Chi Department of Urology, University of California-San Francisco, San Francisco More articles by this author Moyses Szklo Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland More articles by this author Mathew D. Sorensen Department of Urology, School of Medicine, University of Washington, Seattle, Washington Division of Urology, Department of Veterans Affairs Medical Center, Seattle, Washington Division of Urology, Department of Veterans Affairs Medical Center, Seattle, Washington More articles by this author Expand All Advertisement PDF downloadLoading ...