上睑下垂
HMGB1
神经炎症
炎症体
神经科学
小胶质细胞
电离辐射
活性氧
医学
细胞生物学
化学
生物
内科学
炎症
辐照
物理
核物理学
作者
Long Xu,Haiqin Huang,Tianqing Liu,Tao Yang,Xuan Yi
出处
期刊:Neuroscience
[Elsevier]
日期:2022-01-01
卷期号:481: 99-110
被引量:10
标识
DOI:10.1016/j.neuroscience.2021.11.023
摘要
The widespread application of ionizing radiation in industrial and medical fields leads to the increased brain exposure to X-rays. Radiation brain injury (RBI) seriously affects health of patients by causing cognitive dysfunction and neuroinflammation. However, the link between X-ray exposure and depressive symptoms and their detailed underlying mechanisms have not been well studied. Herein, we investigated the potential depression-like behaviors in mice exposed to X-rays and then explored the role of HMGB1 in this injury. We found that X-ray stimulation induced the generation of reactive oxygen species (ROS) in the prefrontal cortex in a dose-dependent manner, leading to the occurrence of depression-like behaviors of the mice. Moreover, X-ray exposure increased the expression of HMGB1, activated NLRP3 inflammasome signaling pathway and microglial cells, and then facilitated the release of pro-inflammatory cytokines, resulting in the pyroptosis and neuron loss both in vivo and in vitro. Additionally, glycyrrhizin (Gly), which is a HMGB1 inhibitor, reversed X-ray-induced behavioral changes and neuronal damage. Our findings indicated that HMGB1-mediated pyroptosis was involved in radiation-induced depression.
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