纳米载体
灰葡萄孢菌
壳聚糖
药物输送
材料科学
阿拉伯树胶
抗真菌药
多重耐药
抗真菌
组合化学
化学
微生物学
有机化学
纳米技术
生物
抗药性
植物
作者
Vinit Raj,Chaitany Jayprakash Raorane,Jin-Hyung Lee
标识
DOI:10.1021/acsami.1c12617
摘要
The treatment of textile wastewater comprising many dyes as contaminants endures an essential task for environmental remediation. In addition, combating antifungal multidrug resistance (MDR) is an intimidating task, specifically owing to the limited options of alternative drugs with multitarget drug mechanisms. Incorporating natural polymeric biomaterials for drug delivery provides desirable properties for drug molecules, effectively eradicating MDR fungal growth. The current study fabricated the bipolymeric drug delivery system using chitosan-gum arabic-coated liposome 5ID nanoparticles (CS-GA-5ID-LP-NPs). This study focused on improving the solubility and sustained release profile of 5I-1H-indole (5ID). These NPs were characterized and tested mechanically as a dye adsorbent as well as their antifungal potencies against the plant pathogen, Botrytis cinerea. CS-GA-5ID-LP-NPs showed 71.23% congo red dye removal compared to crystal violet and phenol red from water and effectively had an antifungal effect on B. cinerea at 25 μg/mL MIC concentrations. The mechanism of the inhibition of B. cinereavia CS-GA-5ID-LP-NPs was attributed to stabilized microtubule polymerization in silico and in vitro. This study opens a new avenue for designing polymeric NPs as adsorbents and antifungal agents for environmental and agriculture remediation.
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