药品
医学
全基因组关联研究
药物遗传学
药理学
基因型
遗传学
生物
单核苷酸多态性
基因
作者
Soyoung Park,Ah Ra,Taesung Park,Sungho Won,Tae‐Bum Kim
标识
DOI:10.1016/j.anai.2021.11.022
摘要
Drug hypersensitivity reactions (DHRs) are type B adverse drug reactions and comprise approximately 15% of all adverse drug reactions. They are mediated by an immunologic mechanism and are currently unpredictable and heterogeneous. 1 Dykewicz MS Lam JK. Drug hypersensitivity reactions. Med Clin North Am. 2020; 104: 109-128 Abstract Full Text Full Text PDF PubMed Scopus (9) Google Scholar DHRs can be life-threatening; therefore, the development of a biomarker that can predict drug hypersensitivity is very important, and genetic biomarkers that predict DHRs are the most studied to date. Several reports indicate that certain HLA types in certain races are associated with DHRs. 2 Pirmohamed M Ostrov DA Park BK. New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity. J Allergy Clin Immunol. 2015; 136: 236-244 Abstract Full Text Full Text PDF PubMed Scopus (68) Google Scholar Nevertheless, their genetic biomarkers have been studied mostly in association with specific drugs and specific races. The highly consistent genetic biomarkers that can predict DHRs regardless of a specific drug and type of reaction can be used to predict and prevent DHRs. In this study, we aimed to identify common genetic biomarkers to predict DHRs by including a cohort of patients with DHRs using genome-wide association study (GWAS).
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