表观基因组
染色质
转录因子
生物
表观遗传学
转录调控
遗传学
T细胞
CD8型
免疫系统
基因
细胞生物学
计算生物学
基因表达
DNA甲基化
作者
Yi Zhong,Scott G. Walker,Yuri Pritykin,Christina Leslie,Alexander Y. Rudensky,Joris van der Veeken
标识
DOI:10.1038/s41590-021-01086-x
摘要
T cell activation, a key early event in the adaptive immune response, is subject to elaborate transcriptional control. In the present study, we examined how the activities of eight major transcription factor (TF) families are integrated to shape the epigenome of naive and activated CD4 and CD8 T cells. By leveraging extensive polymorphisms in evolutionarily divergent mice, we identified the 'heavy lifters' positively influencing chromatin accessibility. Members of Ets, Runx and TCF/Lef TF families occupied the vast majority of accessible chromatin regions, acting as 'housekeepers', 'universal amplifiers' and 'placeholders', respectively, at sites that maintained or gained accessibility upon T cell activation. In addition, a small subset of strongly induced immune response genes displayed a noncanonical TF recruitment pattern. Our study provides a key resource and foundation for the understanding of transcriptional and epigenetic regulation in T cells and offers a new perspective on the hierarchical interactions between critical TFs.
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