化学
异喹啉
芳构化
串联
功能群
组合化学
电子
药物化学
有机化学
催化作用
量子力学
物理
复合材料
材料科学
聚合物
作者
Quan-Xing Zi,Minyan Li,Jielun Cong,Guogang Deng,Shengzu Duan,Meng Jia Yin,Wen Chen,Jing Hong,Xiaodong Yang,Patrick J. Walsh
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-02-25
卷期号:24 (9): 1786-1790
被引量:9
标识
DOI:10.1021/acs.orglett.2c00140
摘要
Herein is introduced the application of "super-electron-donor"(SED) 2-azaallyl anions in a tandem reduction/radical cyclization/radical coupling/aromatization protocol that enables the rapid construction of isoquinolines. The value of this transition-metal-free method is highlighted by the wide range of isoquinoline ethyl amines prepared with good functional group tolerance and yields. An operationally simple gram scale synthesis is also conducted, confirming the scalability.
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