隐球菌病
医学
隐球菌
盖蒂隐球菌
爆发
新生隐球菌
真菌病
氟康唑
真菌病
疾病
重症监护医学
毛霉病
抗真菌
免疫学
微生物学
皮肤病科
生物
病毒学
病理
作者
Eileen K. Maziarz,John R. Perfect
标识
DOI:10.1016/j.idc.2015.10.006
摘要
Cryptococcosis is an invasive mycosis caused by pathogenic encapsulated yeasts in the genus Cryptococcus. Cryptococcus gained prominence as a pathogen capable of widespread disease outbreaks in vulnerable populations. We have gained insight into the pathobiology of Cryptococcus, including the yeast' s capacity to adapt to environmental pressures, exploit new geographic environments, and cause disease in both immunocompromised and apparently immunocompetent hosts. Inexpensive, point-of-care testing makes diagnosis more feasible than ever. The associated worldwide burden and mortality remains unacceptably high. Novel screening strategies and preemptive therapy offer promise at making a sustained and much needed impact on this sugar-coated opportunistic mycosis.
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