金黄色葡萄球菌
材料科学
细菌
纳米颗粒
药物输送
药品
钛
纳米技术
化学
微生物学
药理学
医学
生物
有机化学
遗传学
作者
Ye He,Ké Li,Xin Yang,Jin Leng,Ke Xu,Zhangfu Yuan,Changjian Lin,Bailong Tao,Xuan Li,Jingwei Hu,Liangliang Dai,Ryan Becker,Tony Jun Huang,Kaiyong Cai
出处
期刊:Small
[Wiley]
日期:2021-10-19
卷期号:17 (47)
被引量:31
标识
DOI:10.1002/smll.202102907
摘要
Implant-associated bacterial infections significantly impair the integration between titanium and soft tissues. Traditional antibacterial modifications of titanium implants are able to eliminate bacteria, but the resulting pro-inflammatory reactions are usually ignored, which still poses potential risks to human bodies. Here, a dual drug-loading system on titanium has been developed via the adhesion of a catechol motif-modified methacrylated gelatin hydrogel onto TiO2 nanotubes. Then synthesized CaO2 nanoparticles (NPs) are embedded into the hydrogel, and interleukin-4 (IL-4) is loaded into the nanotubes to achieve both antibacterial and anti-inflammatory properties. The dual drug-loading system can eliminate Staphylococcus aureus (S. aureus) rapidly, attributed to the H2 O2 release from CaO2 NPs. The potential cytotoxicity of CaO2 NPs is also remarkably reduced after being embedded into the hydrogel. More importantly, with the gradual release of IL-4, the dual drug-loading system is capable of modulating pro-inflammatory reactions by inducing M2 phenotype polarization of macrophages. In a subcutaneous infection model, the S. aureus contamination is effectively resolved after 2 days, and the resulting pro-inflammatory reactions are also inhibited after 7 days. Finally, the damaged tissue is significantly recovered. Taken together, the dual drug-loading system exhibits great therapeutic potential in effectively killing pathogens and inhibiting the resulting pro-inflammatory reactions.
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