医学
纤维化
发病机制
肺纤维化
特发性肺纤维化
肺
疾病
免疫系统
间质性肺病
病态的
肺纤维化
病理
免疫学
内科学
作者
Olivier Burgy,Pierre-Simon Bellaye,Guillaume Beltramo,Françoise Goirand,Philippe Bonniaud
出处
期刊:Current Opinion in Pulmonary Medicine
[Ovid Technologies (Wolters Kluwer)]
日期:2020-09-01
卷期号:26 (5): 429-435
被引量:7
标识
DOI:10.1097/mcp.0000000000000706
摘要
Purpose of review Pulmonary fibrosis is a chronic and progressive lung disease involving unclear pathological mechanisms. The present review presents and discusses the major and recent advances in our knowledge of the pathogenesis of lung fibrosis. Recent findings The past months have deepened our understanding on the cellular actors of fibrosis with a better characterization of the abnormal lung epithelial cells observed during lung fibrosis. Better insight has been gained into fibroblast biology and the role of immune cells during fibrosis. Mechanistically, senescence appears as a key driver of the fibrotic process. Extracellular vesicles have been discovered as participating in the impaired cellular cross-talk during fibrosis and deeper understanding has been made on developmental signaling in lung fibrosis. Summary This review emphasizes the contribution of different cell types and mechanisms during pulmonary fibrosis, highlights new insights for identification of potential therapeutic strategies, and underlines where future research is needed to answer remaining open questions.
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