病理
胰腺
上皮样细胞
嗜铬粒蛋白A
生物
清除单元格
人口
血管平滑肌脂肪瘤
癌
医学
免疫组织化学
内分泌学
环境卫生
肾
作者
Giuseppe Zamboni,Maurizio Pea,Guido Martignoni,Carlo Zancanaro,Giuseppe Faccioli,Eliana Gilioli,Paolo Pederzoli,Franco Bonetti
标识
DOI:10.1097/00000478-199606000-00010
摘要
We report a unique, previously unreported pancreatic tumor occurring in a 60-year-old woman who was preoperatively diagnosed on cytoaspiration as having clear cell carcinoma. The resected tumor consisted of a population of large epithelioid cells with clear or eosinophilic, granular cytoplasm, rich in glycogen, with nuclear pleomorphism and no mitotic activity. In spite of the epithelioid appearance, the tumor cells were negative for epithelial (CAM 5.2, KL1, AE1-AE3), endocrine (neuron-specific enolase [NSE], chromogranin A), and acinar (lipase, amylase) markers and positive for actin and melanogenesis-related marker HMB 45. Ultrastructurally, the neoplastic cells showed membrane-bound granules; no evidence of either epithelial or melanocytic differentiation was present. These morphophenotypic features have never been reported in a pancreatic tumor and overlap those of clear cell “sugar” tumor of the lung. The same morphophenotypic features are observed in a family of lesions characterized by the presence of the perivascular epithelioid cell that also includes lymphagiomyomatosis and angiomyolipoma. The present case may be considered a novel member of this family of lesions. We propose this new entity be named clear cell “sugar” tumor of the pancreas.
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