脂肪生成
Wnt信号通路
旁分泌信号
脂肪组织
自分泌信号
脂肪细胞
生物
间充质干细胞
细胞生物学
内分泌学
内科学
信号转导
医学
细胞培养
受体
遗传学
作者
Constantinos Christodoulides,Claire Lagathu,J. Sethi,António Vidal-Puig
标识
DOI:10.1016/j.tem.2008.09.002
摘要
An inability of adipose tissue to expand consequent to exhausted capacity to recruit new adipocytes might underlie the association between obesity and insulin resistance. Adipocytes arise from mesenchymal precursors whose commitment and differentiation along the adipocytic lineage is tightly regulated. These regulatory factors mediate cross-talk between adipose cells, ensuring that adipocyte growth and differentiation are coupled to energy storage demands. The WNT family of autocrine and paracrine growth factors regulates adult tissue maintenance and remodelling and, consequently, is well suited to mediate adipose cell communication. Indeed, several recent reports, summarized in this review, implicate WNT signalling in regulating adipogenesis. Manipulating the WNT pathway to alter adipose cellular makeup, therefore, constitutes an attractive drug-development target to combat obesity-associated metabolic complications.
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