ETS1型
间质细胞
生物
基质
病理
转录因子
癌症研究
肿瘤进展
转移
肿瘤坏死因子α
癌症
基因
免疫组织化学
免疫学
医学
遗传学
作者
Nicolas Wernert,Frédéric Gilles,Véronique Fafeur,Fatima Bouali,Marie-Berthe Raes,Charles Pyke,Thierry Dupressoir,Gerhard Seitz,Bernard Vandenbunder,D Stéhelin
出处
期刊:PubMed
日期:1994-11-01
卷期号:54 (21): 5683-8
被引量:43
摘要
The stroma reaction has an important role in tumor growth, invasion, and metastasis. In various invasive human carcinomas, as well as in a mouse model for tumor invasion, transcripts encoding the transcription factor c-Ets1 were detected within stromal fibroblasts, whereas they were absent in epithelial tumor cells. This expression of c-Ets1 was often increased in fibroblasts directly adjacent to neoplastic cells. Endothelial cells of stromal capillaries were also positive for c-Ets1 expression. In contrast, fibroblasts of corresponding noninvasive lesions and of normal tissues were consistently negative. In cultured human fibroblasts stimulated by basic fibroblast growth factor and tumor necrosis factor alpha, the expression of c-Ets1 correlated with the accumulation of transcripts for potential target genes, collagenase-1 and stromelysin-1. The same correlation was observed in some of the invasive carcinomas investigated. These results suggest that c-Ets1 participates in the regulation of tumor invasion in vivo.
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