免疫衰老
生物
胸腺退化
进化生物学
透视图(图形)
功能(生物学)
内卷(密宗)
免疫学
免疫系统
动物
神经科学
T细胞
意识
人工智能
计算机科学
作者
Daryl P. Shanley,Danielle Aw,Nancy R. Manley,Donald B. Palmer
标识
DOI:10.1016/j.it.2009.05.001
摘要
There is an accumulating body of evidence that a decline in immune function with age is common to most if not all vertebrates. For instance, age-associated thymic involution seems to occur in all species that possess a thymus, indicating that this process is evolutionary ancient and conserved. The precise mechanisms regulating immunosenescence remain to be resolved, but much of what we do know is consistent with modern evolutionary theory. In this review, we assess our current knowledge from an evolutionary perspective on the occurrence of immunosenescence, we show that life history trade-offs play a key role and we highlight the possible advantages of the age-related decline in thymic function.
科研通智能强力驱动
Strongly Powered by AbleSci AI