偏头痛
光环
先兆偏头痛
医学
降钙素基因相关肽
单倍型
内科学
家族性偏瘫性偏头痛
基因
遗传学
受体
等位基因
神经肽
生物
作者
Christa Hohoff,Martin Marziniak,Klaus‐Peter Lesch,Jürgen Deckert,Claudia Sommer,Rainald Mößner
出处
期刊:Cephalalgia
[SAGE]
日期:2007-02-01
卷期号:27 (2): 177-181
被引量:36
标识
DOI:10.1111/j.1468-2982.2007.01254.x
摘要
The adenosine A2A receptor A2AR facilitates effects of calcitonin gene-related peptide and vasoactive intestinal peptide, two important neuropeptides in migraine pathophysiology, and is the molecular target of caffeine, which is used in migraine treatment. We therefore determined whether A2AR gene variation might influence migraine susceptibility. Migraine patients (n = 265) with or without aura and migraine-free controls (n = 154) were assessed and genotyped for six genetic variants spanning the A2AR gene. A six-marker haplotype was more frequent in migraine patients with aura (P < 0.01) but not in patients without aura, compared with the control group. This indicates that A2AR gene variation may contribute to the pathogenesis of migraine with aura.
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