抗生素
水平基因转移
基因转移
动力学(音乐)
人口
选择(遗传算法)
生物
基因
化学
遗传学
医学
计算机科学
物理
声学
环境卫生
人工智能
系统发育树
作者
Allison J. Lopatkin,Sihong Huang,Robert P. Smith,Jaydeep K. Srimani,Tatyana A. Sysoeva,Sharon Bewick,David Karig,You Li
出处
期刊:Nature microbiology
日期:2016-04-11
卷期号:1 (6)
被引量:198
标识
DOI:10.1038/nmicrobiol.2016.44
摘要
It is generally assumed that antibiotics can promote horizontal gene transfer. However, because of a variety of confounding factors that complicate the interpretation of previous studies, the mechanisms by which antibiotics modulate horizontal gene transfer remain poorly understood. In particular, it is unclear whether antibiotics directly regulate the efficiency of horizontal gene transfer, serve as a selection force to modulate population dynamics after such gene transfer has occurred, or both. Here, we address this question by quantifying conjugation dynamics in the presence and absence of antibiotic-mediated selection. Surprisingly, we find that sublethal concentrations of antibiotics from the most widely used classes do not significantly increase the conjugation efficiency. Instead, our modelling and experimental results demonstrate that conjugation dynamics are dictated by antibiotic-mediated selection, which can both promote and suppress conjugation dynamics. Our findings suggest that the contribution of antibiotics to the promotion of horizontal gene transfer may have been overestimated. These findings have implications for designing effective antibiotic treatment protocols and for assessing the risks of antibiotic use.
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