A patient with facial pain and a limited range of mandibular movement underwent an extensive dental/craniomandibular examination. In addition, he had a medical and rheumatological evaluation. A diagnosis of ankylosing spondylitis with secondary involvement of the temporomandibular joints was made. This was clearly differentiated from rheumatoid arthritis. A multidisciplinary approach to treatment was established with excellent cooperation between physicians and dentist. The management of this patient is described.