Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets

糖尿病神经病变 医学 多元醇途径 糖尿病 Wnt信号通路 生物信息学 刺猬信号通路 信号转导 内分泌学 生物 细胞生物学 醛糖还原酶
作者
Saikat Dewanjee,Sonjit Das,Anup Kumar Das,Niloy Bhattacharjee,Anjum Dihingia,Tarun Kumar Dua,Jatin Kalita,Prasenjit Manna
出处
期刊:European Journal of Pharmacology [Elsevier BV]
卷期号:833: 472-523 被引量:253
标识
DOI:10.1016/j.ejphar.2018.06.034
摘要

Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy includes multiple forms, ranging from discomfort to death. Prognosis of diabetic neuropathy is an uphill task as it remains silent for several years after the onset of diabetes. Hyperglycemia, apart from inducing oxidative stress in neurons, also leads to activation of multiple biochemical pathways which constitute the major source of damage and are potential therapeutic targets in diabetic neuropathy. A vast array of molecular pathways, including polyol pathway, hexosamine pathway, PKCs signaling, oxidative stress, AGEs pathway, PARP pathway, MAPK pathway, NF-κB signaling, hedgehog pathways, TNF-α signaling, cyclooxygenase pathway, interleukins, lipoxygenase pathway, nerve growth factor, Wnt pathway, autophagy, and GSK3 signaling may be accounted for the pathogenesis and progression of diabetic neuropathy. Although symptomatic treatment is available for diabetic neuropathy, few treatment options are available to eliminate the root cause. The immense physical, psychological, and economic burden of diabetic neuropathy highlights the need for cost effective and targeted therapies. The main aim of this review is to highlight the putative role of various mechanisms and pathways involved in the development of diabetic neuropathy and to impart an in-depth insight on new therapeutic approaches aimed at delaying or reversing various modalities of diabetic neuropathy.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
3秒前
4秒前
午马未羊完成签到 ,获得积分10
4秒前
4秒前
神奇皮燕子完成签到,获得积分10
5秒前
5秒前
领导范儿应助科研通管家采纳,获得10
6秒前
英姑应助科研通管家采纳,获得10
7秒前
科研通AI5应助科研通管家采纳,获得10
7秒前
无花果应助科研通管家采纳,获得10
7秒前
天天快乐应助科研通管家采纳,获得10
7秒前
科研通AI5应助科研通管家采纳,获得10
7秒前
852应助科研通管家采纳,获得10
7秒前
慕青应助科研通管家采纳,获得10
7秒前
7秒前
7秒前
7秒前
7秒前
伍六七发布了新的文献求助20
10秒前
10秒前
11秒前
糊涂的剑发布了新的文献求助10
11秒前
13秒前
xx发布了新的文献求助10
15秒前
16秒前
酷波er应助糊涂的剑采纳,获得10
17秒前
19秒前
Ava应助Q1n采纳,获得10
22秒前
甜蜜唯雪发布了新的文献求助10
24秒前
SUNNY完成签到 ,获得积分10
26秒前
糊涂的剑完成签到,获得积分10
27秒前
香妃完成签到,获得积分10
29秒前
xx完成签到,获得积分20
31秒前
谨慎雪碧完成签到 ,获得积分10
32秒前
开心的帽子完成签到,获得积分10
34秒前
37秒前
38秒前
彭于晏应助不听话的番茄采纳,获得10
41秒前
科研通AI5应助帅气的祥采纳,获得10
42秒前
高分求助中
【此为提示信息,请勿应助】请按要求发布求助,避免被关 20000
Continuum Thermodynamics and Material Modelling 2000
Encyclopedia of Geology (2nd Edition) 2000
105th Edition CRC Handbook of Chemistry and Physics 1600
Maneuvering of a Damaged Navy Combatant 650
Периодизация спортивной тренировки. Общая теория и её практическое применение 310
Mixing the elements of mass customisation 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3778382
求助须知:如何正确求助?哪些是违规求助? 3324102
关于积分的说明 10217105
捐赠科研通 3039323
什么是DOI,文献DOI怎么找? 1667963
邀请新用户注册赠送积分活动 798447
科研通“疑难数据库(出版商)”最低求助积分说明 758385