Evolution mechanism of scientific topics using inheritance and variation features of knowledge genes: A case study in the hematopoietic stem-cell field

This study explores the key factors and internal driving forces of knowledge creation by constructing a research framework for the evolution of knowledge genes. The evolutionary mechanism of scientific topics is examined through the inheritance and variation characteristics of knowledge genes. Subject–predicate–object triples are used to identify knowledge gene topics, which are further categorised into four types based on their stability and variation features. A knowledge gene evolution path is then developed using content similarity and inheritance across adjacent time slices. Multidimensional feature analysis is applied to explore the inheritance and variation dynamics of these knowledge genes. A case study in the hematopoietic stem cells field, supported by literature validation and expert consultation, demonstrates the effectiveness of this method in enhancing the understanding of the knowledge innovation mechanism.