科克伦图书馆
科学网
医学
药物发现
生物信息学
药理学
传统医学
内科学
生物
荟萃分析
作者
Yang Deng,Wangli Ding,Qiang Peng,Wei Wang,Rui Duan,Yingdong Zhang
出处
期刊:Mini-reviews in Medicinal Chemistry
[Bentham Science]
日期:2024-02-01
卷期号:24 (2): 139-158
被引量:1
标识
DOI:10.2174/1389557523666230328134932
摘要
Abstract: AVE 0991, a non-peptide analogue of Angiotensin-(1-7) [Ang-(1-7)], is orally active and physiologically well tolerated. Several studies have demonstrated that AVE 0991 improves glucose and lipid metabolism, and contains anti-inflammatory, anti-apoptotic, anti-fibrosis, and anti-oxidant effects. Numerous preclinical studies have also reported that AVE 0991 appears to have beneficial effects on a variety of systemic diseases, including cardiovascular, liver, kidney, cancer, diabetes, and nervous system diseases. This study searched multiple literature databases, including PubMed, Web of Science, EMBASE, Google Scholar, Cochrane Library, and the ClinicalTrials.gov website from the establishment to October 2022, using AVE 0991 as a keyword. This literature search revealed that AVE 0991 could play different roles via various signaling pathways. However, the potential mechanisms of these effects need further elucidation. This review summarizes the benefits of AVE 0991 in several medical problems, including the COVID-19 pandemic. The paper also describes the underlying mechanisms of AVE 0991, giving in-depth insights and perspectives on the pharmaceutical value of AVE 0991 in drug discovery and development.
科研通智能强力驱动
Strongly Powered by AbleSci AI