Engineering Ultra‐Small Cerium‐Based Metal–Organic Frameworks Nanozymes for Efficient Antioxidative Treatment of Dry Eye Disease (Adv. Funct. Mater. 6/2024)

Advanced Functional MaterialsVolume 34, Issue 6 2470034 Inside Back CoverFree Access Engineering Ultra-Small Cerium-Based Metal–Organic Frameworks Nanozymes for Efficient Antioxidative Treatment of Dry Eye Disease (Adv. Funct. Mater. 6/2024) Zhongxing Chen, Zhongxing Chen Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Fudan University, Shanghai, 200030 P. R. China Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200030 P. R. ChinaSearch for more papers by this authorZheng Li, Zheng Li Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Fudan University, Shanghai, 200030 P. R. China Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200030 P. R. China School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027 P. R. ChinaSearch for more papers by this authorNana Tang, Nana Tang Department of Ophthalmology, Lu'an People's Hospital of Anhui Province, Lu'an Hospital Affiliated to Anhui Medical University, Lu'an, Anhui, 237000 P. R. ChinaSearch for more papers by this authorYida Huang, Yida Huang The Affiliated Eye Hospital, Naniing Medical University, Nanjing, 200025 P. R. ChinaSearch for more papers by this authorSiheng Li, Siheng Li School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027 P. R. ChinaSearch for more papers by this authorWenjin Xu, Wenjin Xu School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027 P. R. ChinaSearch for more papers by this authorQing Wang, Qing Wang Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Fudan University, Shanghai, 200030 P. R. China Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Jiangxi, 330000 P. R. ChinaSearch for more papers by this authorXin Chen, Xin Chen Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Fudan University, Shanghai, 200030 P. R. China Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200030 P. R. ChinaSearch for more papers by this authorNan Zhao, Nan Zhao Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Fudan University, Shanghai, 200030 P. R. China Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200030 P. R. China School of Chemical Engineering, Northeast Electric Power University, Jilin, 132000 P. R. ChinaSearch for more papers by this authorZhenhai Zeng, Zhenhai Zeng Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Fudan University, Shanghai, 200030 P. R. China Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200030 P. R. ChinaSearch for more papers by this authorYichen Xiao, Yichen Xiao Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Fudan University, Shanghai, 200030 P. R. China Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200030 P. R. ChinaSearch for more papers by this authorXinyi Chen, Xinyi Chen Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Fudan University, Shanghai, 200030 P. R. China Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200030 P. R. China School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027 P. R. ChinaSearch for more papers by this authorJiawei Li, Jiawei Li School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027 P. R. China Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Fudan University, Shanghai, 200030 P. R. China Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200030 P. R. ChinaSearch for more papers by this authorXingtao Zhou, Xingtao Zhou Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Fudan University, Shanghai, 200030 P. R. China Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200030 P. R. ChinaSearch for more papers by this authorGuisheng Li, Guisheng Li School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, 200093 P. R. ChinaSearch for more papers by this authorMei Yang, Mei Yang Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Fudan University, Shanghai, 200030 P. R. China Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200030 P. R. ChinaSearch for more papers by this authorJinhai Huang, Jinhai Huang Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Fudan University, Shanghai, 200030 P. R. China Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200030 P. R. ChinaSearch for more papers by this author Zhongxing Chen, Zhongxing Chen Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Fudan University, Shanghai, 200030 P. R. China Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200030 P. R. ChinaSearch for more papers by this authorZheng Li, Zheng Li Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Fudan University, Shanghai, 200030 P. R. China Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200030 P. R. China School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027 P. R. ChinaSearch for more papers by this authorNana Tang, Nana Tang Department of Ophthalmology, Lu'an People's Hospital of Anhui Province, Lu'an Hospital Affiliated to Anhui Medical University, Lu'an, Anhui, 237000 P. R. ChinaSearch for more papers by this authorYida Huang, Yida Huang The Affiliated Eye Hospital, Naniing Medical University, Nanjing, 200025 P. R. ChinaSearch for more papers by this authorSiheng Li, Siheng Li School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027 P. R. ChinaSearch for more papers by this authorWenjin Xu, Wenjin Xu School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027 P. R. ChinaSearch for more papers by this authorQing Wang, Qing Wang Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Fudan University, Shanghai, 200030 P. R. China Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Jiangxi, 330000 P. R. ChinaSearch for more papers by this authorXin Chen, Xin Chen Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Fudan University, Shanghai, 200030 P. R. China Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200030 P. R. ChinaSearch for more papers by this authorNan Zhao, Nan Zhao Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Fudan University, Shanghai, 200030 P. R. China Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200030 P. R. China School of Chemical Engineering, Northeast Electric Power University, Jilin, 132000 P. R. ChinaSearch for more papers by this authorZhenhai Zeng, Zhenhai Zeng Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Fudan University, Shanghai, 200030 P. R. China Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200030 P. R. ChinaSearch for more papers by this authorYichen Xiao, Yichen Xiao Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Fudan University, Shanghai, 200030 P. R. China Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200030 P. R. ChinaSearch for more papers by this authorXinyi Chen, Xinyi Chen Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Fudan University, Shanghai, 200030 P. R. China Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200030 P. R. China School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027 P. R. ChinaSearch for more papers by this authorJiawei Li, Jiawei Li School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027 P. R. China Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Fudan University, Shanghai, 200030 P. R. China Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200030 P. R. ChinaSearch for more papers by this authorXingtao Zhou, Xingtao Zhou Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Fudan University, Shanghai, 200030 P. R. China Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200030 P. R. ChinaSearch for more papers by this authorGuisheng Li, Guisheng Li School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, 200093 P. R. ChinaSearch for more papers by this authorMei Yang, Mei Yang Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Fudan University, Shanghai, 200030 P. R. China Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200030 P. R. ChinaSearch for more papers by this authorJinhai Huang, Jinhai Huang Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Fudan University, Shanghai, 200030 P. R. China Shanghai Research Center of Ophthalmology and Optometry, Shanghai, 200030 P. R. ChinaSearch for more papers by this author First published: 05 February 2024 https://doi.org/10.1002/adfm.202470034AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract Ultrasmall Ce-MOFs Nanozymes ln article number 2307569, Xingtao Zhou, Guisheng Li, Mei Yang, Jinhai Huang, and co-workers develop ultra-small cerium-based metal organic frameworks (Ce-MOFs) nanozymes for efficient antioxidative treatment of dry eye disease (DED). The obtained ultra-small Ce-MOF 3 (2 nm) exhibits superior ROS scavenging and antioxidant capacity, decreased cytotoxicity, and excellent ocular penetration. Therapeutically, Ce-MOF 3 is demonstrated to be highly efficient in alleviating DED by suppressing oxidative stress and inflammation, boosting corneal epithelial repair, and facilitating tear secretion recovery. Volume34, Issue6February 5, 20242470034 RelatedInformation