银屑病
特应性皮炎
孟德尔随机化
痤疮
肠道菌群
皮肤病科
免疫学
生物
微生物群
医学
遗传学
基因型
遗传变异
基因
作者
Fei Feng,Ruicheng Li,Rui Tian,Xiao-Ming Wu,Nannan Zhang,Zhenhua Nie
出处
期刊:PLOS ONE
[Public Library of Science]
日期:2024-03-21
卷期号:19 (3): e0298443-e0298443
标识
DOI:10.1371/journal.pone.0298443
摘要
Increasing evidence suggests that alterations in gut microbiota are associated with a variety of skin diseases. However, whether this association reflects a causal relationship remains unknown. We aimed to reveal the causal relationship between gut microbiota and skin diseases, including psoriasis, atopic dermatitis, acne, and lichen planus.We obtained full genetic association summary data for gut microbiota, psoriasis, atopic dermatitis, acne, and lichen planus from public databases and used three methods, mainly inverse variance weighting, to analyze the causal relationships between gut microbiota and these skin diseases using bidirectional Mendelian randomization, as well as sensitivity and stability analysis of the results using multiple methods.The results showed that there were five associated genera in the psoriasis group, seven associated genera were obtained in the atopic dermatitis group, a total of ten associated genera in the acne group, and four associated genera in the lichen planus group. The results corrected for false discovery rate showed that Eubacteriumfissicatenagroup (P = 2.20E-04, OR = 1.24, 95%CI:1.11-1.40) and psoriasis still showed a causal relationship. In contrast, in the reverse Mendelian randomization results, there was no evidence of an association between these skin diseases and gut microbiota.We demonstrated a causal relationship between gut microbiota and immune skin diseases and provide a new therapeutic perspective for the study of immune diseases: targeted modulation of dysregulation of specific bacterial taxa to prevent and treat psoriasis, atopic dermatitis, acne, and lichen planus.
科研通智能强力驱动
Strongly Powered by AbleSci AI