Distinct microtubule networks mediate neuronal migration and polarization

During cortical development, microtubules simultaneously mediate neuronal migration up toward cortical plate and axon extension down toward white matter. Using new molecular tools to manipulate microtubule nucleation and dynamics, in this issue of Neuron, Vinopal et al. 1 Vinopal S. Dupraz S. Alfadil E. Pietralla T. Bendre S. Stiess M. Falk S. Camargo Ortega G. Maghelli N. Tolić I.M. et al. Centrosomal microtubule nucleation regulates radial migration of projection neurons independently of polarization in the developing brain. Neuron. 2023; 111: 1241-1263https://doi.org/10.1016/j.neuron.2023.01.020 Abstract Full Text Full Text PDF PubMed Scopus (3) Google Scholar identify the distinct microtubule networks underpinning these processes. During cortical development, microtubules simultaneously mediate neuronal migration up toward cortical plate and axon extension down toward white matter. Using new molecular tools to manipulate microtubule nucleation and dynamics, in this issue of Neuron, Vinopal et al. 1 Vinopal S. Dupraz S. Alfadil E. Pietralla T. Bendre S. Stiess M. Falk S. Camargo Ortega G. Maghelli N. Tolić I.M. et al. Centrosomal microtubule nucleation regulates radial migration of projection neurons independently of polarization in the developing brain. Neuron. 2023; 111: 1241-1263https://doi.org/10.1016/j.neuron.2023.01.020 Abstract Full Text Full Text PDF PubMed Scopus (3) Google Scholar identify the distinct microtubule networks underpinning these processes. Centrosomal microtubule nucleation regulates radial migration of projection neurons independently of polarization in the developing brainVinopal et al.NeuronFebruary 15, 2023In BriefCombining a novel expression system with live in vivo imaging, three-dimensional two-photon imaging, and centrosomal ablation, Vinopal and Dupraz et al. demonstrate that neurons need centrosomal microtubule nucleation for their radial migration but not axon formation. Full-Text PDF Open Access