免疫系统
炎症
分泌物
垃圾箱
线粒体
生物
DNA损伤
细胞生物学
免疫学
化学
DNA
生态学
遗传学
生物化学
作者
Manuel M. Gómez de las Heras,Marı́a Mittelbrunn
出处
期刊:Nature Aging
日期:2023-04-20
卷期号:3 (5): 475-476
标识
DOI:10.1038/s43587-023-00412-2
摘要
The mysteries behind immune aging and its related inflammation are being unmasked. Jin et al. reveal that the defective turnover of damaged mitochondria in CD4+ T cells from older individuals results in the exacerbated secretion of mitochondrial DNA, which fuels inflammaging and impairs immune responses.
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