生物
PRDM16
关贸总协定6
褐色脂肪组织
细胞生物学
脂肪生成
祖细胞
中胚层
胚胎干细胞
细胞分化
转录因子
干细胞
脂肪组织
内分泌学
遗传学
间充质干细胞
基因
作者
Sung Hoon Jun,Anthony R. Angueira,Ethan C. Fein,Josephine M.E. Tan,Angela H. Weller,Lan Cheng,Kirill Batmanov,Jeff Ishibashi,Alexander P. Sakers,Rachel R. Stine,Patrick Seale
标识
DOI:10.1016/j.devcel.2023.08.003
摘要
Brown adipose tissue (BAT) is a thermogenic organ that protects animals against hypothermia and obesity. BAT derives from the multipotent paraxial mesoderm; however, the identity of embryonic brown fat progenitor cells and regulators of adipogenic commitment are unclear. Here, we performed single-cell gene expression analyses of mesenchymal cells during mouse embryogenesis with a focus on BAT development. We identified cell populations associated with the development of BAT, including Dpp4+ cells that emerge at the onset of adipogenic commitment. Immunostaining and lineage-tracing studies show that Dpp4+ cells constitute the BAT fascia and contribute minorly as adipocyte progenitors. Additionally, we identified the transcription factor GATA6 as a marker of brown adipogenic progenitor cells. Deletion of Gata6 in the brown fat lineage resulted in a striking loss of BAT. Together, these results identify progenitor and transitional cells in the brown adipose lineage and define a crucial role for GATA6 in BAT development.
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