基质金属蛋白酶
血脑屏障
砷
衰老
化学
内分泌学
内科学
生物
医学
中枢神经系统
有机化学
作者
Man Lv,Xinbo Ma,Kunyu Zhang,Meichen Zhang,Ji Yi,Lin Chen,Xiaofei Shao,Guan Zhang,Chengzao Jia,Yanhui Gao,Yang Liu,Yanmei Yang,Xiaona Liu
标识
DOI:10.1016/j.cbi.2023.110743
摘要
Accumulating evidence suggests that Matrix metalloproteinase-9 (MMP-9) and −2 (MMP-2) are involved in the neuropathological processes by contributing to breaking the extracellular matrix and the tight junctions that constitute the blood-brain barrier (BBB). However, the influences of arsenic (As) on these two MMPs were inconsistent. In the cross-sectional study of 500 adults, serum MMP-2 and MMP-9 positively correlated with urine arsenic. And the positive correlation between urine tAs and serum MMP-9/2 was found in people older than 59 years. In vivo studies, we found that arsenic exposure or senescence might decrease number of neurons and neuritic density and increase serum and cortical MMP-9/2 levels. Furthermore, arsenic exposure or senescence could disrupt the tight junction of BBB and elevate MMP-9 and MMP-2 expression in the cerebral microvascular endothelium. The MMP-9 and MMP-2 are of particular interest when researching the link between arsenic exposure and nerve damage.
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