催汗剂
医学
四分位间距
轴突反射
反射
内科学
胆碱能的
心脏病学
自主神经系统
肾上腺素能的
内分泌学
心率
血压
受体
作者
Timo Siepmann,Martin Arndt,Annahita Sedghi,Szabolcs Szatmári,Tamás Horváth,Annamária Takáts,Dániel Bereczki,Mats Leif Moskopp,Sylvia J. Buchmann,Cornelia Skowronek,Wagner Zago,Warunya Woranush,Razvan Lapuska,Marie Luise Weidemann,Christopher H. Gibbons,Roy Freeman,Heinz Reichmann,Volker Puetz,Kristian Barlinn,A. Pintér,Ben Min-Woo Illigens
摘要
We characterized autonomic pilomotor and sudomotor skin function in early Parkinson's disease (PD) longitudinally.We enrolled PD patients (Hoehn and Yahr 1-2) and healthy controls from movement disorder centers in Germany, Hungary, and the United States. We evaluated axon-reflex responses in adrenergic sympathetic pilomotor nerves and in cholinergic sudomotor nerves and assessed sympathetic skin response (SSR), predominantly parasympathetic neurocardiac function via heart rate variability, and disease-related symptoms at baseline, after 2 weeks, and after 1 and 2 years.gov: NCT03043768.We included 38 participants: 26 PD (60% females, aged 62.4 ± 7.4 years, mean ± SD) and 12 controls (75% females, aged 59.5 ± 5.8 years). Pilomotor function was reduced in PD compared to controls at baseline when quantified via spatial axon-reflex spread (78 [43-143], median [interquartile range] mm2 vs. 175 [68-200] mm2 , p = 0.01) or erect hair follicle count in the axon-reflex region (8 [6-10] vs. 11 [6-16], p = 0.008) and showed reliability absent any changes from baseline to Week 2 (p = not significant [ns]). Between-group differences increased over the course of 2 years (p < 0.05), although no decline was observed within groups (p = ns). Pilomotor impairment in PD correlated with motor symptoms (rho = -0.59, p = 0.017) and was not lateralized (p = ns). Sudomotor axon-reflex and neurocardiac function did not differ between groups (p = ns), but SSR was reduced in PD (p = 0.0001).Impairment of adrenergic sympathetic pilomotor function and SSR in evolving PD is not paralleled by changes to cholinergic sudomotor function and parasympathetic neurocardiac function, suggesting a sympathetic pathophysiology. A pilomotor axon-reflex test might be useful to monitor PD-related pathology.
科研通智能强力驱动
Strongly Powered by AbleSci AI