神经突
神经科学
磁共振成像
正电子发射断层摄影术
磁共振弥散成像
神经退行性变
τ蛋白
神经影像学
阿尔茨海默病
心理学
核磁共振
医学
化学
病理
疾病
物理
放射科
生物化学
体外
作者
Philip S.J. Weston,William Coath,Matthew J Harris,Ian Malone,John Dickson,Franklin I. Aigbirhio,David M. Cash,Hui Zhang,Jonathan M. Schott
摘要
Abstract Introduction In Alzheimer's disease (AD), hyperphosphorylated tau is closely associated with focal neurodegeneration, but the mechanism remains uncertain. Methods We quantified cortical microstructure using neurite orientation dispersion and density imaging in 14 individuals with young onset AD. Diffusion tensor imaging measured mean diffusivity (MD). Amyloid beta and tau positron emission tomography were acquired and associations with microstructural measures were assessed. Results When regional volume was adjusted for, in the medial temporal lobe there was a significant negative association between neurite density and tau (partial R 2 = 0.56, p = 0.008) and between orientation dispersion and tau (partial R 2 = 0.66, p = 0.002), but not between MD and tau. In a wider cortical composite, there was an association between orientation dispersion and tau (partial R 2 = 0.43, p = 0.030), but not between other measures and tau. Discussion Our findings are consistent with tau causing first dendritic pruning (reducing dispersion/complexity) followed by neuronal loss. Advanced magnetic resonance imaging (MRI) microstructural measures have the potential to provide information relating to underlying tau deposition.
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