FYN公司
白杨素
神经炎症
炎症体
药理学
小胶质细胞
化学
NF-κB
细胞生物学
癌症研究
信号转导
炎症
酪氨酸激酶
医学
免疫学
生物
生物化学
受体
类黄酮
抗氧化剂
作者
Qingchen Wang,Zhiping Yang,Xin-Tong Wu,Xiao Zhang,Feng Geng,Qiaoyun Wang,Zikai Geng,Yu Chen,Zhipeng Li
标识
DOI:10.1016/j.intimp.2022.109118
摘要
Fyn, a non-receptor tyrosine kinase, plays an important role in microglial-mediated neuroinflammation and may serve as a candidate therapeutic target for neuropsychiatric diseases. In this study, we discovered that chrysin, a natural flavonoid compound, suppressed the activation of Fyn kinase and further alleviated neuroinflammation-induced neuron damage and behavior deficits. Functionally, chrysin improved lipopolysaccharide (LPS)-induced memory impairment and depressive behaviors in mice, it also protected against LPS-induced neuronal degeneration and loss and synaptic defects in mice. Our study demonstrated that chrysin inhibited the activation of microglia and reduced the expression of NLRP3 and IL-1β. Furthermore, our data indicated that chrysin blocked phosphorylation of Fyn and activation of NF-κB. Transfection with siRNA-Fyn validated that knockdown of Fyn partly abolished the inhibitory effect of chrysin on the expression of the NLRP3 inflammasome and NF-κB activation. Taken together, our findings revealed that chrysin alleviated LPS-induced neuron damage and behavioral deficits by inhibiting the expression of the NLRP3 inflammasome and NF-κB pathway, which might be mediated by inhibition of Fyn.
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