化学
区域选择性
齿合度
SN2反应
过渡金属
催化作用
组合化学
基质(水族馆)
药物化学
金属
立体化学
有机化学
海洋学
地质学
作者
Jiaojiao Liu,Liang Yuan,Yan Wu,Gang Wang,Chuan‐Zhi Yao,Jie Yu,Qiankun Li
标识
DOI:10.1021/acs.orglett.4c01008
摘要
1,2-Bis(diphenylphosphino)ethanes (DPPEs) are versatile and immensely important ligands in transition metal catalysts. Here we report the dithiophosphinylation of readily available allenyl acetates to give DPPEs in high yields and regioselectivity. This protocol features a broad substrate scope and mild conditions, avoiding the use of transition metals and air-sensitive sources of phosphorus. Mechanism studies indicate that the reaction was accomplished via an SN2′-type addition–elimination followed by a 1,4-addition step.
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