对映选择合成
催化作用
甲酰胺类
双金属片
化学
产量(工程)
镍
药物化学
有机化学
材料科学
冶金
作者
Yin–Xia Wang,Feng-Ping Zhang,Hao Chen,Yue Li,Jiang-Fei Li,Mengchun Ye
标识
DOI:10.1002/anie.202209625
摘要
Abstract Enantioselective Ni‐catalyzed C(sp 3 )−H bond activation remains an elusive challenge. Herein, we used phosphine oxide‐ligated Ni−Al bimetallic catalyst to realize enantioselective Ni‐catalyzed aliphatic C(sp 3 )−H activation of formamides, providing a series of chiral N‐containing heterocycles in 40–95 % yield and 70–95 % ee.
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