氰化
艾地明
催化作用
化学
对映选择合成
产量(工程)
氢键
反应性(心理学)
基础(拓扑)
Strecker胺基酸合成
有机化学
组合化学
高分子化学
分子
材料科学
数学
病理
数学分析
医学
冶金
替代医学
作者
Yun‐Hui Zhao,Yueyang Luo,Jun Lee,Changwu Zheng,Gang Zhao
标识
DOI:10.1002/chem.202302061
摘要
A highly enantioselective cyanation of imines (up to >99 % ee) has been developed using well-designed C2 -symmetric hydrogen bonding catalysts. The catalytic strategy was characterized with low catalyst loading (0.1-1 mol %), easily accessible catalysts with diverse functional groups, and catalytic base additives. A wide range of imines, including the challenging N-Boc and N-Cbz protected ketimines and aldimines, as well as fluoroalkylated ketimines, were investigated under mild conditions to afford the products with good to excellent yields (up to 99 % yield) and high enantioselectivity (up to >99 % ee). Control experiments revealed that the multiple hydrogen bonding catalysts enhanced the reactivity and enantioselectivity of the Strecker reaction initiated by the base.
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