生物
端粒
衰老
背景(考古学)
免疫系统
炎症
免疫学
细胞生物学
CD8型
T淋巴细胞
遗传学
DNA
古生物学
作者
Phatthamon Laphanuwat,Daniel Cláudio Oliveira Gomes,Arne N. Akbar
摘要
Summary As the thymus involutes during aging, the T‐cell pool has to be maintained by the periodic expansion of preexisting T cells during adulthood. A conundrum is that repeated episodes of activation and proliferation drive the differentiation of T cells toward replicative senescence, due to telomere erosion. This review discusses mechanisms that regulate the end‐stage differentiation (senescence) of T cells. Although these cells, within both CD4 and CD8 compartments, lose proliferative activity after antigen‐specific challenge, they acquire innate‐like immune function. While this may confer broad immune protection during aging, these senescent T cells may also cause immunopathology, especially in the context of excessive inflammation in tissue microenvironments.
科研通智能强力驱动
Strongly Powered by AbleSci AI