佐米曲普坦
运动障碍
医学
交叉研究
丁螺环酮
苄丝肼
随机对照试验
普拉克索
帕金森病
左旋多巴
内科学
苏马曲普坦
兴奋剂
替代医学
安慰剂
受体
疾病
病理
作者
Peter A. LeWitt,Glenn T. Stebbins,Kenneth Vielsted Christensen,Ratna N G B Tan,Anél Pretorius,Mikael S. Thomsen
摘要
Abstract Background Preclinical evidence suggests that co‐administration of the 5‐HT 1A agonist buspirone and the 5‐HT 1B/1D agonist zolmitriptan act synergistically to reduce dyskinesia to a greater extent than that achieved by either drug alone. Objectives Assess the therapeutic potential of a fixed‐dose buspirone and zolmitriptan combination in Parkinson's disease (PD) patients with levodopa‐induced dyskinesia. Methods Single‐center, randomized, placebo‐controlled, two‐way crossover study (NCT02439203) of a fixed‐dose buspirone/zolmitriptan regimen (10/1.25 mg three times a day) in 30 patients with PD experiencing at least moderately disabling peak‐effect dyskinesia. Results Seven days of treatment with buspirone/zolmitriptan added to levodopa significantly reduced dyskinesia as assessed by Abnormal Involuntary Movement Scale scores versus placebo (mean treatment effect vs. placebo: −4.2 [−6.1, −2.3]) without significantly worsening Unified Parkinson's Disease Rating Scale (UPDRS) Part III (ON) scores (mean treatment effect vs. placebo: 0.6 [−0.1, 1.3]). No serious adverse events were reported. Conclusions In this proof‐of‐concept study, addition of buspirone/zolmitriptan to the patients’ PD medication regimen significantly reduced dyskinesia severity without worsening motor function. © 2024 International Parkinson and Movement Disorder Society.
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