材料科学
再生(生物学)
伤口愈合
生物医学工程
纳米技术
外科
细胞生物学
医学
生物
作者
Shunxiang Xu,Yuantao Zhang,Bingyang Dai,Jiancun Rao,Feilong Deng,Shian Zhang,Hongwei Shao,Li Xu,Zhi Jin,Tongzhou Liang,Yongkang Yang,Yucong Li,Ziyi Chen,Wenxue Tong,Rui‐Hua Xu,Congqin Ning,Ling Qin
标识
DOI:10.1002/adfm.202307439
摘要
Abstract Bioceramics provide promising tactics for wound healing, yet the on‐shelf products are still unmet, especially for skin appendages regeneration. Herein, the inorganic magnesium silicate sprays (MSS) as mineral factors to overcome the existing challenges is proposed. Results indicate MSS can be synthesized by a green method without organic solvents, templates, calcination, and harmful by‐products. With amorphous phase, nanoscale, and high specific surface area, MSS reveal an improved pH‐responsive degradability and excellent bioactivity for cell proliferation and migration. In rats, MSS display a dose‐dependent effect on accelerating burn‐wound repair via regulating the expressions of iNOS and IL‐10 to attenuate inflammation, elevating the expressions of CD31 and α‐SMA to improve vascularization, and boosting collagen deposition without ectopic calcification. The released Mg and Si ions synergistically potentiate the expressions of Gap43 , Tubb3 , and K19 , suggesting the regeneration of peripheral nerves and hair follicles. These superior features are further verified by comparisons with commercial products, Dermlin® and 45S5 bioglass®, in both rats and minipigs. Motivated by these findings, three MSS‐based formulations of band‐aid patch, adhesive hydrogel, and antibacterial sprays are devised for specific scenarios. Taken together, this proof‐of concept study provides a promising bioactive mineral for future clinical skin wound repair and functional appendages regeneration.
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