心肌细胞
神经科学
再生(生物学)
人口
医学
计算生物学
生物信息学
生物
细胞生物学
内科学
环境卫生
作者
Jing Jin,Yurou Wang,Yueqin Liu,Subrata Chakrabarti,Zhaoliang Su
标识
DOI:10.1016/j.apsb.2023.12.018
摘要
Cardiac resident macrophages (CRMs) are the main population of cardiac immune cells. The role of these cells in regeneration, functional remodeling, and repair after cardiac injury is always the focus of research. However, in recent years, their dynamic changes and contributions in physiological states have a significant attention. CRMs have specific phenotypes and functions in different cardiac chambers or locations of the heart and at different stages. They further show specific differentiation and development processes. The present review will summarize the new progress about the spatiotemporal distribution, potential developmental regulation, and their roles in cardiac development and aging as well as the translational potential of CRMs on cardiac diseases. Of course, the research tools for CRMs, their respective advantages and disadvantages, and key issues on CRMs will further be discussed.
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