过氧化氢酶
超氧化物歧化酶
化学
脂多糖
氧化应激
红细胞
谷胱甘肽过氧化物酶
谷胱甘肽
血红蛋白
生物化学
三磷酸腺苷
氧化磷酸化
酶
免疫学
生物
作者
Yue Chen,Zhen Liu,Huaze Shao,Jun Xu,Jincheng Li,Haoyi Chen,Chun‐Qiong Zhou,Lihong Liu
出处
期刊:Current Pharmaceutical Biotechnology
[Bentham Science]
日期:2023-11-01
卷期号:24 (14): 1795-1802
标识
DOI:10.2174/1389201024666230330134044
摘要
Introduction: Alterations in red blood cell deformability (RBC-df) provide important information for the diagnosis of various diseases. Aim: We evaluated individual differences of lipopolysaccharide (LPS)-induced oxidative damage of RBC-df and analyzed the correlation between RBC-df and biochemical parameters. Methods: A microfluidic chip was developed to detect inter-individual variability of different concentrations of LPS-induced oxidative damage of RBC-df in 9 healthy volunteers. The relationships between various biochemical indicators (Na+-K+-ATPase activity, lipid peroxide (LPO) content, glutathione peroxidase (GSH-PX) activity, catalase (CAT) activity, superoxide dismutase (SOD) activity, adenosine triphosphate (ATP) content, and hemoglobin (HB) content) and RBCsdf were investigated. Results: The obvious inter-individual variability of LPS-induced oxidative damage of RBC-df was revealed. The Na+-K+-ATPase activity, LPO content, GSH-PX activity, and CAT activity of RBCs showed significant correlations with RBC-df (P < 0.05). Conclusion: Oxidative damage and energy metabolism are the critical factors of RBC-df impairment induced by LPS, and the individual dependence on RBC-df is an important indicator for the treatment of infection-associated sepsis since antibiotics can kill pathogenic bacteria, which results in the release of LPS from the cell wall.
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