视神经脊髓炎
光谱紊乱
多中心研究
医学
怀孕
儿科
中国
自闭症谱系障碍
精神科
多发性硬化
外科
政治学
自闭症
生物
随机对照试验
法学
遗传学
作者
Yitong Huang,Yuge Wang,Yifan Zhou,Qiao Huang,Xiaobo Sun,Chen Chen,Ling Fang,Youming Long,Hui Yang,Honghao Wang,Caixia Li,Zhengqi Liu,Xueqiang Hu,Allan G. Kermode
标识
DOI:10.1016/j.jns.2016.11.054
摘要
This study aimed to assess the effect of pregnancy on the course of neuromyelitis optica spectrum disorder (NMOSD), and the effect of this disease on pregnancy outcomes.Consecutive patients with NMOSD were recruited between September 2015 and April 2016 at an outpatient clinic from four referral institutes in South China. Demographic, clinical, and pregnancy data were retrieved by questionnaires to analyze the association between NMOSD and pregnancy, as well as the potential risk factors for relapse.Among 249 patients with NMOSD, 55 had pregnancy-related attacks. The annual relapse rate in the first (3.20±6.82) and second (3.25±3.32) 3-month postpartum periods was marginally higher than that before pregnancy (1.44±0.92, p=0.682) and during pregnancy (1.23±1.32, p=0.758). The Kurtzke Expanded Disability Status Scale score increased from 1.55±0.38 before pregnancy to 2.88±2.14 at postpartum (p<0.001). NMOSD significantly increased the premature birth rate in patients after disease onset (8.33%) compared with before disease onset (1.95%, p=0.025). Multivariate analysis showed that negative anti-aquaporin-4 IgG, concomitance with autoimmune diseases/antibodies, and no treatment in remission were risk factors of recurrence.Our study shows a significant association between pregnancy and NMOSD in the Chinese population. Larger scale prospective studies are warranted in the future.
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