托珠单抗
视神经脊髓炎
医学
发病机制
自身抗体
白细胞介素6
白细胞介素-6受体
免疫学
抗体
受体
白细胞介素
内科学
细胞因子
类风湿性关节炎
作者
Takashi Yamamura,Manabu Araki
出处
期刊:Brain and nerve
日期:2014-10-01
卷期号:66 (10): 1159-65
被引量:1
标识
DOI:10.11477/mf.1416200004
摘要
Our lab has previously shown that Interleukin (IL)-6- dependent production of autoantibodies against aquaporin 4 in plasmablasts may play a central role in the pathogenesis of neuromyelitis optica (NMO). In this study, we explored the efficacy of tocilizumab, a humanized antibody against IL-6 receptor, in intractable cases of NMO. Eight NMO patients who were unresponsive to current treatments received monthly injections of tocilizumab for at least one year. Tocilizumab significantly reduced the annual relapse rate, neurogenic pain, and fatigue in NMO patients. These results indicate that IL-6 signaling plays a crucial role in the pathogenesis of NMO and highlight the value of IL-6 receptor inhibition for the treatment of NMO.
科研通智能强力驱动
Strongly Powered by AbleSci AI