Iridium‐Catalyzed β‐C(sp2)−H Borylation of Enamides – Access to 3,3‐Dihalogeno‐2‐methoxypiperidines

Abstract An efficient catalytic preparation of synthetically useful new β‐borylated enamides was achieved under relatively mild conditions via a regioselective iridium‐catalyzed C(sp 2 )−H borylation. The method features broad substrate scope, good functional group tolerance and efficient scale‐up. These C‐3 borylated enamides can be advantageously exploited in cross‐coupling reactions and converted into valuable 3,3‐dihalogeno‐2‐methoxypiperidines in very short reaction times.