肠道菌群
肠道微生物群
感觉
神经科学
睡眠(系统调用)
微生物群
生物
心理学
医学
肠-脑轴
生物信息学
免疫学
计算机科学
社会心理学
操作系统
作者
Paromita Sen,Alicia Molinero-Perez,Kenneth J. O’Riordan,Cian McCafferty,Ken D. O’Halloran,John F. Cryan
标识
DOI:10.1016/j.molmed.2021.07.004
摘要
Various lifestyle and environmental factors are known to influence sleep. Increasingly, evidence points to a role for the microbiota in regulating brain and behaviour. This article explores how the microbiota-gut-brain axis affects sleep directly and indirectly. We summarize the possible molecular mechanisms underlying sleep-microbiome interactions and discuss how various factors interact with the gut microbiota to influence sleep. Furthermore, we present the current evidence of alterations of the microbiota-gut-brain axis in various sleep disorders and pathologies where comorbid sleep disturbances are common. Since manipulating the gut microbiota could potentially improve sleep, we outline ways in which this can be achieved.
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