肿瘤微环境
癌症研究
癌症免疫疗法
免疫疗法
巨噬细胞
免疫系统
癌症
化学
癌细胞
铁转运蛋白
炎症
医学
免疫学
海西定
内科学
肿瘤细胞
体外
生物化学
作者
Zhaohan Wei,Xiaoqiong Zhang,Zelong Zhang,Tuying Yong,Guiting Zhan,Weilin Lv,Ziqiao Ding,Kaili Sun,Xiangliang Yang,Lu Gan
标识
DOI:10.1016/j.cej.2021.133847
摘要
Resetting M2-like tumor-associated macrophages (TAMs) to antitumor M1 phenotype is a promising strategy in cancer immunotherapy. Although iron-based nanoparticles exhibit the potential of M2-to-M1 macrophage repolarization, the efficient M2-like TAM targeting and the subsequent intracellular iron retention remains a big challenge. Here, M2 macrophage-targeting peptide-conjugated iron-based metal–organic frameworks are developed to load diclofenac ([email protected]) for enhanced cancer immunotherapy. [email protected] efficiently targets M2-like TAMs and decreases the efflux by hepcidin/ferroportin signaling pathway, enabling enhanced intracellular accumulation for improved M2-to-M1 macrophage repolarization. [email protected] M2-like TAMs efficiently kill and phagocytose tumor cells, and importantly remodel tumor immune microenvironment to generate long-term antitumor immune memory, eliciting strong anticancer efficacy with tumor recurrence inhibition. Our results support [email protected] as a potential drug for cancer immunotherapy.
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