纳米载体
药物输送
没食子酸
沸石咪唑盐骨架
葡萄糖氧化酶
Zeta电位
材料科学
咪唑酯
核化学
化学
药品
纳米技术
金属有机骨架
有机化学
纳米颗粒
药理学
生物传感器
医学
抗氧化剂
吸附
作者
Münteha Özsoy,Vesen Atiroğlu,Gamze Güney Eskiler,Atheer Atiroğlu,Gülnur Arabacı,Mahmut Özacar
标识
DOI:10.1016/j.jddst.2023.104878
摘要
Zeolitic imidazolate framework-8 (ZIF-8) nanostructures exhibit pH-sensitive drug release properties, making them highly promising for anticancer drug delivery systems. In our study, we synthesized Fe-doped ZIF-8 metal–organic framework (MOF) structures modified with gallic acid (GA) as a drug delivery system. Our objective was to enhance the therapeutic effectiveness of the drug carriers by incorporating glucose oxidase (GOx) or gold (Au) additives. The successful fabrication of nanocarriers and their structural properties were confirmed using SEM, TEM, FTIR, zeta potential, XRD, and TGA analyses. The designed ZIF-8-based nano drug carriers demonstrated high encapsulation efficiency for the anticancer drug 5-fluorouracil (5-FU). In vitro drug release studies at pH 5 and pH 7.4 revealed the increased release of 5-FU from ZIF-8@GA@Fe@5-FU, ZIF-8@GA@Fe@5-FU@GOx, and ZIF-8@GA@Fe@5-FU@Au, primarily due to the acid-labile degradation of ZIF-8 at pH 5. Among these formulations, ZIF-8@GA@Fe@5-FU@GOx exhibited the most significant impact, inducing apoptosis and causing notable morphological alterations in MDA-MB-231 breast cancer cell lines. Additionally, the ZIF-8@GA@Fe@5-FU formulation, along with ZIF-8@GA@Fe@5-FU@Au, exhibited intriguing luminescence properties. The obtained results demonstrate the potential of these developed drug delivery systems (DDSs) as viable alternatives for breast cancer cell lines. The unique properties of ZIF-8-based nanostructures, combined with the incorporation of GA and the potential addition of GOx or Au, offer promising opportunities for enhancing the targeted delivery and efficacy of anticancer drugs.
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