生物利用度
环糊精
药品
抗生素
抗菌活性
药理学
药物输送
化学
抗生素耐药性
生物技术
细菌
组合化学
医学
生物
有机化学
生物化学
遗传学
作者
Anamaria Mendonça Santos,José Adão Carvalho Nascimento Júnior,Silvia VS Cézar,Adriano Antunes de Souza Araújo,Lucindo José Quintans‐Júnior,Diana Marcela Aragón,Mairim Russo Serafini
出处
期刊:Future Microbiology
[Future Medicine]
日期:2023-11-01
标识
DOI:10.2217/fmb-2023-0124
摘要
Aim: The study aimed to review experimental models using cyclodextrins to improve antibacterial drugs' physicochemical characteristics and biological activities. Methods: The following terms and their combinations were used: cyclodextrins and antibacterial agents in title or abstract, and the total study search was conducted over a period up to October 2022. The review was carried out using PubMed, Scopus and Embase databases. A total of 1580 studies were identified, of which 27 articles were selected for discussion in this review. Results: The biological results revealed that the antibacterial effect of the inclusion complexes was extensively improved. Cyclodextrins can enhance the therapeutic effects of antibiotics already existing on the market, natural products and synthetic molecules. Conclusion: Overall, CDs as drug-delivery vehicles have been shown to improve antibiotics solubility, stability, and bioavailability, leading to enhanced antibacterial activity.The overuse of drugs can cause bacteria to become less susceptible to them. This is known as resistance. One idea on how to tackle this resistance is by using cyclodextrins (CDs). CDs can change how drugs work, making them better at fighting bacteria. As CDs are already used in making drugs, they are a good choice for the basis of creating new drugs.
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