分子内力
材料科学
高脂血症
聚集诱导发射
智能材料
骨料(复合)
纳米技术
分子
发光
吸收(声学)
生物物理学
光电子学
光学
化学
复合材料
有机化学
生物
物理
内分泌学
荧光
糖尿病
作者
Feiyi Sun,Wei Zhao,Hanchen Shen,Ni Fan,Jianyu Zhang,Qingqing Liu,Changhuo Xu,Jiyuan Luo,Mengying Zhao,Yuyang Chen,Kristy W. K. Lam,Xueqin Yang,Ryan T. K. Kwok,Jacky W. Y. Lam,Jianwei Sun,Hongfei Zhang,Ben Zhong Tang
标识
DOI:10.1002/adma.202207671
摘要
Molecular aggregates with environmental responsive properties are desired for their wide practical applications such as bioprobes. Here, a series of smart near-infrared (NIR) luminogens for hyperlipidemia (HLP) diagnosis is reported. The aggregates of these molecules exhibit a twisted intramolecular charge-transfer effect in aqueous media, but aggregation-induced emission in highly viscous media due to the restriction of the intramolecular motion. These aggregates, which can autonomously respond to different environments via switching the aggregation state without changing their chemical structures are described, as "smart aggregates". Intriguingly, these luminogens demonstrate NIR-II and NIR-III luminescence with ultralarge Stokes shifts (>950 nm). Both in vitro detection and in vivo imaging of HLP can be realized in a mouse model. Linear relationships exist between the emission intensity and multiple pathological parameters in blood samples of HLP patients. Thus, the design of smart aggregate facilitates rapid and accurate detection of HLP and provides a promising attempt in aggregate science.
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