Sex differences in cardiac electrophysiology

Apart from a faster resting heart rate, the increased duration of the rate-corrected QTc interval likely is the most known and the most prominent physiological electrocardiographic difference between healthy adult females and males.1 In earlier reports, this sex difference was inflated by the use of the Bazett correction, which, combined with higher and lower heart rates, produces artificially prolonged and shortened QTc intervals, respectively. Nevertheless, the QTc sex difference is present even with more accurate, that is, subject-specific corrections.