金念珠菌
米卡芬金
遮罩(插图)
微生物学
葡聚糖
医学
化学
生物
抗真菌
生物化学
氟康唑
艺术
视觉艺术
作者
Mark V. Horton,Emily F Eix,Chad Johnson,M. Dean,Brody D Andes,Kayla M Wartman,Jeniel E. Nett
标识
DOI:10.1093/infdis/jiae043
摘要
Abstract Invasive fungal pathogen Candida auris has become a public health threat causing outbreaks of high mortality infections. Drug resistance often limits treatment options. For Candida albicans, subinhibitory concentrations of echinocandins unmask immunostimulatory β-glucan, augmenting immunity. Here we analyze the impact of echinocandin treatment of C. auris on β-glucan exposure and human neutrophil interactions. We show subinhibitory concentrations lead to minimal glucan unmasking and only subtle influences on neutrophil functions for the isolates belonging to circulating clades. The data suggest that echinocandin treatment will not largely alter phagocytic responses. Glucan masking pathways appear to differ between C. auris and C. albicans.
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