太空飞行
压电1
纤维化
医学
衰老
内科学
内分泌学
机械敏感通道
受体
离子通道
航空航天工程
工程类
作者
Jiaxin Zhang,Xinpei Wang,Zihao Fu,Changyang Xing,Zhen Wang,Hongyan Yang,Jiahui Li,Meijie Liu,Dong Liu,Zhen Xing,Yongzhi Li,Jiaping Wang,Jiang Long,Ke Cao,Shengpeng Wang,Jia Li,Feng Gao
出处
期刊:Cardiovascular Research
[Oxford University Press]
日期:2024-01-25
摘要
Abstract Aims Elucidating the impacts of long-term spaceflight on cardiovascular health is urgently needed in face of the rapid development of human space exploration. Recent reports including the NASA Twins Study on vascular deconditioning and aging of astronauts in spaceflight are controversial. The aims of this study were to elucidate whether long-term microgravity promotes vascular aging and the underlying mechanisms. Methods and results Hindlimb unloading (HU) by tail suspension was used to simulate microgravity in rats and mice. The dynamic changes of carotid stiffness in rats during 8 weeks of HU were determined. Simulated microgravity led to carotid artery aging-like changes as evidenced by increased stiffness, thickness, fibrosis and elevated senescence biomarkers in the HU rats. Specific deletion of the mechanotransducer Piezo1 in vascular smooth muscles significantly blunted these aging-like changes in mice. Mechanistically, mechanical stretch-induced activation of Piezo1 elevated microRNA-582-5p in vascular smooth muscle cells, with resultant enhanced synthetic cell phenotype and increased collagen deposition via PTEN/PI3K/Akt signaling. Importantly, inhibition of miRNA-582-5p alleviated carotid fibrosis and stiffness not only in HU rats but also in aged rats. Conclusions Long-term simulated microgravity induces carotid aging-like changes via the mechanotransducer Piezo1-initiated and miRNA-mediated mechanism.
科研通智能强力驱动
Strongly Powered by AbleSci AI