Argininosuccinate lyase drives activation of mutant TERT promoter in glioblastomas

(Molecular Cell 82, 3919–3931.e1–e7; October 20, 2022) In the originally published version of this article, the Graphical Abstract and Figure S7C contained a typo, “KD5MC,” which should have been “KDM5C.” In the original Figure 3E, the y axis legend was omitted; this should have been “% of input.” These errors have now been corrected online. The authors apologize for any concern or inconvenience this might have caused. Figure 3E. ASL S417 phosphorylation facilitates H3K4me3 active mark on TERT promoter-mutant regions (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure S7C. ASL S417 phosphorylation positively correlates with telomerase activities in GBM patients, Related to Figure 7 (corrected)View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure S7C. ASL S417 phosphorylation positively correlates with telomerase activities in GBM patients, Related to Figure 7 (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) Argininosuccinate lyase drives activation of mutant TERT promoter in glioblastomasShi et al.Molecular CellOctober 20, 2022In BriefShi et al. report that through interacting with GABPA, S417-phosphorylated ASL locates on mutant regions of TERT promoters, where it generates fumarate to inhibit KDM5C and subsequently facilitates enrichment of H3K4me3 in these regions. This event promotes the recruitment of c-Myc for TERT transcription and GBM tumorigenesis. Full-Text PDF