成纤维细胞
细胞生物学
心力衰竭
化学
细胞外基质
循环系统
刺激
基质(化学分析)
射血分数
细胞信号
信号转导
癌症研究
体外
人的心脏
Ⅰ型胶原
病理生理学
生物
医学
作者
Alexander Lynge Reese‐Petersen,Federica Genovese,Lei Zhao,G. Banks,David A. Gordon,M.A. Karsdal
标识
DOI:10.3389/fmolb.2023.1228232
摘要
Extracellular matrix proteins harbor signaling domains that once released from the parent molecule can trigger cellular responses. One of these molecules is endotrophin, a type VI collagen derived fragment, whose circulatory levels have been associated to an increased risk of adverse outcome in heart failure with preserved ejection fraction (HFpEF). Here we show that the stimulation of human cardiac fibroblasts by endotrophin upregulates the synthesis of type I collagen, the main interstitial collagen that accumulates in the myocardium during fibrogenesis. These data provide a possible mechanistic explanation for the relation between circulating endotrophin levels and risk of outcome in HFpEF.
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