神经病理性疼痛
麦吉尔疼痛调查表
简短疼痛清单
医学
帕金森病
物理疗法
疾病
伤害
焦虑
慢性疼痛
内科学
麻醉
精神科
可视模拟标度
受体
作者
Veit Mylius,Santiago Pérez Lloret,Rubens Gisbert Cury,Manoel Jacobsen Teixeira,Victor R Barbosa,Egberto Reis Barbosa,Larissa Iulle Moreira,Clarice Listik,Ana Mércia Fernandes,Diogo de Lacerda Veiga,Julio Barbour,Nathalie Hollenstein,Matthias Oechsner,Julia Walch,Florian Brugger,Stefan Hägele-Link,Serafin Beer,Alexandra Rizos,K. Ray Chaudhuri,Didier Bouhassira,Jean‐Pascal Lefaucheur,Lars Timmermann,Roman Gonzenbach,Georg Kägi,Jens Carsten Möller,Daniel Ciampi de Andrade
出处
期刊:Pain
[Ovid Technologies (Wolters Kluwer)]
日期:2020-10-08
卷期号:162 (4): 1201-1210
被引量:40
标识
DOI:10.1097/j.pain.0000000000002107
摘要
Pain is a common nonmotor symptom in patients with Parkinson disease (PD) but the correct diagnosis of the respective cause remains difficult because suitable tools are lacking, so far. We developed a framework to differentiate PD- from non-PD-related pain and classify PD-related pain into 3 groups based on validated mechanistic pain descriptors (nociceptive, neuropathic, or nociplastic), which encompass all the previously described PD pain types. Severity of PD-related pain syndromes was scored by ratings of intensity, frequency, and interference with daily living activities. The PD-Pain Classification System (PD-PCS) was compared with classic pain measures (ie, brief pain inventory and McGill pain questionnaire [MPQ], PDQ-8 quality of life score, MDS-UPDRS scores, and nonmotor symptoms). 159 nondemented PD patients (disease duration 10.2 ± 7.6 years) and 37 healthy controls were recruited in 4 centers. PD-related pain was present in 122 patients (77%), with 24 (15%) suffering one or more syndromes at the same time. PD-related nociceptive, neuropathic, or nociplastic pain was diagnosed in 87 (55%), 25 (16%), or 35 (22%), respectively. Pain unrelated to PD was present in 35 (22%) patients. Overall, PD-PCS severity score significantly correlated with pain's Brief Pain Inventory and MPQ ratings, presence of dyskinesia and motor fluctuations, PDQ-8 scores, depression, and anxiety measures. Moderate intrarater and interrater reliability was observed. The PD-PCS is a valid and reliable tool for differentiating PD-related pain from PD-unrelated pain. It detects and scores mechanistic pain subtypes in a pragmatic and treatment-oriented approach, unifying previous classifications of PD-pain.